URIC ACID CAUSES
Why do levels of acid uric increase?
The causes which can raise uric acid concentration may be primary or secondary. The secondary can be subdivided according to whether they are linked to food or are associated with the occurrence of some other disease.
Primary causes of the increase in uric acid
The root causes can be inherited. They can occur when endogenous production increases because of changes in uric acid secretion in our body or they can be caused by a fault in the purines metabolism.
We should note that the regeneration of muscle tissue of our own body produces small amounts of uric acid and an increased need for such regeneration, for whatever reason (cancer or other diseases), can also increase these levels.
Secondary or acquired causes of increased uric acid
The food that we eat directly influences the appearance and therefore the severity of this disease.
As already mentioned above, one of the causes that can lead to the accumulation of uric acid is fasting and so is making a caloric overeating, but they are not the only reasons relating to the type of food we eat.
Making an excessive consumption in the intake of foods high in purines is also one of the most common causes of increased uric acid. This is what happens when eating nucleic acids present in viscera, young animal meat, etc.
Drinking alcohol, when you have uric acid levels increased, is also detrimental. Alcohol intake varies hepatic metabolism of uric acid. That’s to say, it stops its processing, so uric acid accumulates in the body.
Other causes that sometimes are not related to this increase also have their potentiating action, such as the intake of foods rich in fructose and / or sucrose, for example, a high consumption of fruits, juices, etc.
A poor diet can adversely affect our intestinal flora, which, being diminished, may not exercise its action of elimination of uric acid as it should.
It can also appear as a secondary cause of increased illness:
– Diseases of cholesterol and triglycerides (dyslipidemia). Foods that are high in purines also usually high in cholesterol (not all), so, if excess uric acid is due to the diet that the patient performs regularly, it can result in overweight or obesity, arteriosclerosis, etc.
Foods that are rich in fructose and sucrose (sugar) also imply an rise in triglyceride level,s which may cause or aggravate obesity.
– Diseases with hyperglycemia: When a person has insulin resistance, urate reabsorption is higher and its concentration in blood increases. Insulin resistance is when the body can not properly use glucose for energy, so it accumulates in the blood and levels of both become unbalanced (hyperglycemia and hyperinsulinemia take place). A disease called diabetes mellitus type II develops.
A side effect of hyperglycemia and imbalance in a patient with poorly controlled diabetes is the formation of ketone bodies or also called ketosis. These substances, that also acidify the blood, are formed when the the body uses fat to produce the energy required for the survival of the organism.
This system is also activated when we perform weight loss diets where carbohydrate intake is minimal and insufficient. The problem arises when you are overweight or obese along with an accumulation of uric acid and lose weight is recommended. First, it is of utmost importance to stabilize the levels of uric acid in the blood, before attempting to reduce weight. Once they are stable, you can start a diet, but you need to do it together with these guidelines to basify body. (See uric acid remedies in the listing above)
States of metabolic acidosis (also called lactic or respiratory acidosis) that is caused by lack of oxygen to the tissues after physical exercise or it can be easily attributable to obese people, also acidifies the blood.
– Diseases of rapid cell division: A rise of uric acid because of the appearance of malignancy may take place, for example, because of the destruction of various blood cells, such as in some cancer types as myeloma, leukemia and lymphomas, in which cells such as leukocytes are affected and altered.
It may also increase because of a disease such as psoriasis whose process of cellular regeneration of the skin is greatly increased. In the last two cases the rapid proliferation affects cell multiplication and exacerbates acidosis level in our body.
– Infectious diseases: It can also increase as a result of contracting a viral character disease, such as infectious mononucleosis, also known as the kissing disease. This virus is from the same family as the herpes simplex virus.
– Kidney diseases: The accumulation of uric acid can lead to the formation of kidney stones. Unlike other cases, these stones or grit are not calcareous (from calcium), but they are formed with uric acid. It can also cause acute or chronic renal failure.
An inadequate water intake, or even if the submission is correct but there are high losses (excessive sweating, intense physical exercise, etc..) in conjunction with a diet too acidic, may incur deficiencies in kidney function as an acute or chronic renal failure.
These diseases, involving a decrease in renal system functionality, leads to a less elimination of toxic substances through the kidneys and, therefore, excessive uric acid can not be eliminated in order to maintain the normal levels in the blood.
Failure of kidney function of removing toxins can also be a secondary cause of having to take some drugs, such as antiretroviral, diuretics, laxatives, TB, etc..
A decrease in blood volume (hypovolemia), implies that blood reaching the kidneys is diminished, so there is less filtration of toxins, which could potentially increase the levels of uric acid in it.
– Other diseases: Furthermore, a state of hyperthyroidism or chronic poisoning by heavy metals such as lead, can be indirect causes of the accumulation of uric acid and thus the appearance of hyperuricemia.
More information on uric acid.